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Evidence by topic

How has hyperbaric oxygen been studied in chronic wounds?

13 papers. Randomized human trials: 1. Human studies without a control group: 3. Reviews and literature analyses: 8. Animal studies: 1.

Publication dates from 1 January 2025 to 29 October 2026. Titles and abstracts were searched for hyperbaric oxygen with chronic, nonhealing or hard to heal wounds. Wounds of causes other than diabetes are also included.

Checked 2026-10-29 · 31 records searched

Randomized human trials1

  1. 48 patients with chronic wounds requiring negative pressure wound care were randomized across multiple centers to added hyperbaric oxygen (24) or negative pressure care alone (24); wound size changes, pain scores and bacterial contamination were compared.

    JPRAS Open · 2025 · PMID 40502361

    DOI 10.1016/j.jpra.2025.05.001Record and abstractFree full text

Human studies without a control group3

  1. A case report of 1 man aged 61 with a chronic thigh wound after a spider bite receiving excision, skin grafting, negative pressure wound care and hyperbaric oxygen, monitored with photographs and microperfusion measurements.

    J Clin Med · 2026 · PMID 41598629

    DOI 10.3390/jcm15020693Record and abstractFree full text

  2. A case series of 6 patients with persistent chronic wounds receiving hyperbaric oxygen; laser speckle imaging measured perfusion in healthy skin, wound margins and wound beds before and after sessions.

    Int Wound J · 2026 · PMID 42830258

    DOI 10.1111/iwj.71075Record and abstractFree full text

  3. A case report of 1 woman aged 75 with Cogan syndrome, pyoderma gangrenosum and a nonhealing surgical wound, documenting antibiotics, debridement and steroids followed by 4 cyclophosphamide infusions and hyperbaric oxygen.

    Skin Health Dis · 2025 · PMID 40124997

    DOI 10.1093/skinhd/vzae027Record and abstractFree full text

Reviews and literature analyses8

  1. A narrative review of 11 screened studies of hyperbaric oxygen and conventional care across chronic wound types, covering measures such as wound area, closure, pain and quality of life. Total participant count is not reported in the abstract.

    Cureus · 2025 · PMID 41116954

    DOI 10.7759/cureus.92728Record and abstractFree full text

  2. A scoping review of 54 clinical and 45 preclinical studies of gas based approaches to chronic wounds, searching Medline, Embase and Scopus for hyperbaric oxygen, topical gases and gas delivery formulations. Total participant count is not reported in the abstract.

    Eur J Pharm Biopharm · 2025 · PMID 41106558

    DOI 10.1016/j.ejpb.2025.114894Record and abstract

  3. A review of clinical research and application conditions for hyperbaric oxygen in chronic wounds including diabetic foot wounds. The abstract does not report the number of included papers or total participants.

    Ther Umsch · 2025 · PMID 41569276

    DOI 10.23785/tu.2025.06.003Record and abstract

  4. A systematic review of 18 studies involving 1,281 patients in plastic surgery indications including wounds, grafts and flaps; 786 received hyperbaric oxygen and 495 did not, across observational studies, case series and randomized trials.

    Plast Reconstr Surg Glob Open · 2026 · PMID 42559634

    DOI 10.1097/gox.0000000000007989Record and abstractFree full text

  5. A review of glucose and lipid related literature and management approaches in chronic diabetic wounds, discussing hyperbaric oxygen alongside drugs, dressings and negative pressure wound care. The abstract does not report the number of included papers or total participants.

    Metabol Open · 2025 · PMID 41321406

    DOI 10.1016/j.metop.2025.100408Record and abstractFree full text

  6. A literature review of chronic wounds in irradiated skin, examining approaches including hyperbaric oxygen, dermal substitutes and fat or plasma derived products, with animal studies and case reports. The abstract does not report the number of included papers or total participants.

    Adv Wound Care (New Rochelle) · 2026 · PMID 41313654

    DOI 10.1177/21621918251400347Record and abstract

  7. A review of hyperbaric oxygen trials and meta-analyses in diabetic foot ulcers as one chronic wound type, also examining wound physiology and participant selection. The abstract does not report the number of included papers or total participants.

    J Diabetes Complications · 2025 · PMID 39970800

    DOI 10.1016/j.jdiacomp.2025.108973Record and abstract

  8. A literature review of molecular mechanisms and management approaches for chronic diabetic wounds, including hyperbaric oxygen among several approaches. The abstract does not report the number of included papers or total participants.

    Curr Diabetes Rev · 2026 · PMID 40511645

    DOI 10.2174/0115733998368222250509185511Record and abstract

Animal studies1

  1. Rats with diabetes received full thickness dorsal skin wounds and polymer hydrogel, hyperbaric oxygen or combined conditions; tissue, collagen, tensile strength, redox markers and gene expression were analyzed. Sample size is not reported in the abstract.

    Tissue Cell · 2026 · PMID 40896868

    DOI 10.1016/j.tice.2025.103113Record and abstract

18 of 31 records excluded: no abstract (1), an oxygen carrier review rather than hyperbaric oxygen (1), commentary without an abstract (1), a nanoparticle review rather than hyperbaric oxygen (1), a study guide on osteomyelitis rather than a journal study (1), cognitive measurements rather than wound progression (1), tumor and muscle oxygen measurements rather than wounds (1), a tendon cell experiment rather than chronic skin wounds (1), general wound care commentary without distinct hyperbaric oxygen data (1), a hydrogel review rather than hyperbaric oxygen (1), a platelet rich plasma case rather than hyperbaric oxygen (1), a sleep breathing disorder review rather than wounds (1), biomaterials literature rather than hyperbaric oxygen (1), a YouTube video analysis rather than clinical research (1), an insurance policy analysis rather than wound research (1), nanoparticle and photothermal interventions rather than hyperbaric oxygen (1), a review focused on hydrogen peroxide rather than hyperbaric oxygen (1), local oxygen delivery rather than hyperbaric oxygen (1).

View the search query

TITLE_ABS:"hyperbaric oxygen" AND (TITLE_ABS:"chronic wound" OR TITLE_ABS:"chronic wounds" OR TITLE_ABS:"nonhealing wound" OR TITLE_ABS:"non-healing wound" OR TITLE_ABS:"hard-to-heal") AND FIRST_PDATE:[2025-01-01 TO 2026-10-29] AND (SRC:MED OR SRC:PMC)

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Frequently asked questions

Are wounds other than diabetic foot ulcers included?

Yes. Cases and reviews also cover nonhealing surgical wounds, a chronic wound after a spider bite and wounds in irradiated skin.

What did the randomized groups receive?

In the 48 person study, 24 received negative pressure wound care plus hyperbaric oxygen and 24 received negative pressure care alone. It did not compare hyperbaric oxygen alone with no care.

Do papers overlap with the diabetic foot page?

Yes. Diabetic foot wounds can be chronic wounds, so some reviews appear on both pages. Adding the page counts would count those papers twice.