How has hydrogen inhalation been studied in diabetes?
6 papers. Other comparative human studies: 1. Human studies without a control group: 2. Animal studies: 3.
Title and abstract search of MED and PMC records in Europe PMC, with no lower publication date limit and an upper limit of 29 October 2026. Every returned record was screened.
Checked 2026-10-29 · 9 records searched
Other comparative human studies1
Records of 1,088 people with type 2 diabetes were analyzed retrospectively. Groups with and without adjunctive hydrogen inhalation were matched by propensity scores and compared over six months for HbA1c, glucose, lipids and adverse events.
Front Endocrinol (Lausanne) · 2022 · PMID 36743938
Human studies without a control group2
A retrospective multicenter study followed records of 431 people with type 2 diabetes receiving adjunctive hydrogen inhalation over six months, assessing HbA1c, glucose, weight and lipids at four visits without a control group.
Diabetes Metab Syndr Obes · 2023 · PMID 37431394
One patient with diabetic peripheral neuropathy and peripheral artery disease received hydrogen inhalation alongside external counterpulsation, electrical stimulation, a carbon dioxide footbath and other measures; pain, walking distance and vascular and neurological measurements were followed.
Healthcare (Basel) · 2025 · PMID 41228043
Animal studies3
Mouse models of diabetic, dermatitis related and cholestatic itch received 2% hydrogen inhalation or hydrogen rich saline injections; scratching behavior and spinal oxidative stress were assessed. Animal n was not reported in the abstract.
Redox Biol · 2025 · PMID 39752998
In rats with streptozotocin induced diabetes, hydrogen inhalation and hydrogen rich saline were compared using glucose, motor nerve conduction and nerve tissue oxidative stress measurements. Animal n was not reported in the abstract.
Med Gas Res · 2023 · PMID 36204786
A mouse model of diabetic cardiomyopathy was used to study hydrogen inhalation, metformin and their combination; cardiac function, tissue morphology and cell death and fibrosis pathways were analyzed. Animal n was not reported in the abstract.
Free Radic Biol Med · 2022 · PMID 35304269
Excluded 3 records. Study of fatty liver rather than diabetes: 1. Review of sudden hearing loss rather than diabetes: 1. Study of Parkinson disease rather than diabetes: 1.
View the search query
(TITLE_ABS:"hydrogen inhalation" OR TITLE_ABS:"hydrogen gas inhalation" OR TITLE_ABS:"inhalation of hydrogen" OR TITLE_ABS:"hydrogen-oxygen inhalation") AND (TITLE_ABS:diabetes OR TITLE_ABS:diabetic) AND (SRC:MED OR SRC:PMC) AND FIRST_PDATE:[* TO 2026-10-29]
Search Europe PMCFrequently asked questions
Are randomized trials included?
The human papers directly studying diabetes in this search comprise one retrospective comparative study, one retrospective single arm study and one case report. No randomized trial was included.
What did the human studies measure?
The two retrospective studies recorded HbA1c and glucose among other measures. The case report followed pain, walking distance and vascular and neurological measurements.
Was hydrogen always applied on its own?
No. Human studies with adjunctive use and a case involving several concurrent interventions are included.