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Evidence by topic

How has hydrogen inhalation been studied in sleep?

Nine papers: four randomized human trials, two human studies without a control group and three animal studies.

Title and abstract search for hydrogen inhalation together with sleep.

Checked 2026-10-29 · 14 records searched

Randomized human trials4

  1. 66 adults with sleep disorders inhaled a hydrogen-oxygen mix or a control gas through the nose for 7 days; sleep quality, depression and anxiety scales and actigraphy were compared (single-blind).

    Med Gas Res · 2026 · PMID 40826930

    DOI 10.4103/mgr.medgasres-d-25-00020Record and abstractFree full text

  2. 184 surgical patients aged 65+ were randomized; 153 were analyzed (83 hydrogen, 70 control); postoperative delirium and sleep quality before and 7 days after surgery were measured.

    J Pers Med · 2022 · PMID 36675728

    DOI 10.3390/jpm13010067Record and abstractFree full text

  3. 150 day-surgery patients inhaled a 66.7% hydrogen mix or a nitrogen mix around surgery; the main outcome was recovery quality, with sleep quality as an exploratory measure (double-blind).

    Sci Rep · 2026 · PMID 42436242

    DOI 10.1038/s41598-026-61287-yRecord and abstract

  4. 22 healthy young adults, after 24 hours without sleep, received creatine, hydrogen inhalation, caffeine or placebo; brain oxygenation and attention were compared.

    Nutr Health · 2026 · PMID 42904673

    DOI 10.1177/02601060261499900Record and abstract

Human studies without a control group2

  1. 82 patients with advanced cancer inhaled hydrogen and were followed for 3 to 46 months; fatigue, insomnia, appetite and pain were self-reported.

    Med Gas Res · 2019 · PMID 31552873

    DOI 10.4103/2045-9912.266985Record and abstractFree full text

  2. 6 COPD patients added hydrogen inhalation (30 minutes, three times a day, 30 days) to standard care; symptom scores, lung function and sleep quality were compared before and after.

    Medicina (Kaunas) · 2024 · PMID 38399533

    DOI 10.3390/medicina60020245Record and abstractFree full text

Animal studies3

  1. BALB/c mice in an asthma experiment inhaled hydrogen for 7 days; a separate ICR mouse sleep experiment compared 1, 3 and 5 days of inhalation with controls, measuring sleep duration and latency. Animal n not reported in the abstract.

    Sichuan Da Xue Xue Bao Yi Xue Ban · 2020 · PMID 32220191

    DOI 10.12182/20200360103Record and abstract

  2. 22 normal and 33 cardiomyopathic hamsters underwent intermittent hypoxia or normoxia for 14 days. Some cardiomyopathic hamsters inhaled 3.05% hydrogen; cardiac structure and function were measured.

    Am J Physiol Heart Circ Physiol · 2014 · PMID 25281567

    DOI 10.1152/ajpheart.00228.2014Record and abstract

  3. 62 mice exposed to intermittent hypoxia and 13 normoxic controls were studied. Hydrogen at 1.3% was inhaled during reoxygenation, hypoxia or throughout 7 days; cardiac and lipid measures were compared.

    Am J Physiol Heart Circ Physiol · 2011 · PMID 21642501

    DOI 10.1152/ajpheart.00150.2011Record and abstract

Excluded 5 records: two case reports combining multiple interventions for other conditions, two studies using intravenous or oral administration, and one brain edema trial without a sleep assessment described in its abstract.

View the search query

TITLE_ABS:("hydrogen inhalation" OR "inhaled hydrogen" OR "hydrogen gas" OR "hydrogen-oxygen" OR oxyhydrogen) AND TITLE_ABS:(sleep OR insomnia) NOT TITLE_ABS:("hydrogen sulfide" OR "hydrogen peroxide") AND (SRC:MED OR SRC:PMC)

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Frequently asked questions

How many papers studied people?

Four randomized trials and two studies without a control group.

Are animal studies included?

Three studies in mice and hamsters are grouped separately from human studies.

How was sleep measured?

The human studies include sleep quality questionnaires and wrist actigraphy.