How has hydrogen inhalation been studied in oxidative stress?
10 papers. Randomized human trials: 1. Other comparative human studies: 1. Human studies without a control group: 1. Animal studies: 6. Studies combining animal and cell experiments: 1.
Title and abstract search of MED and PMC records in Europe PMC, with first publication dates from 1 January 2025 to 29 October 2026. Every returned record was screened. This is a recent literature window, not an inventory of earlier studies.
Checked 2026-10-29 · 13 records searched
Randomized human trials1
20 patients with locally advanced head and neck cancer were randomized to chemoradiotherapy alone or with hydrogen inhalation; serum metabolites and adverse events were assessed before and after in 19 participants.
Cancers (Basel) · 2026 · PMID 42512258
Other comparative human studies1
31 healthy athletes were divided into control (14), infrared blanket (9) and hydrogen inhalation (8) groups; blood oxidative stress and inflammatory markers were compared before and after winter training. Random allocation was not stated in the abstract.
J Thorac Dis · 2025 · PMID 40950921
Human studies without a control group1
One older woman with suspected sarcopenia received exercise, nutritional guidance and hydrogen inhalation for three months; grip strength, walking speed, inflammatory and oxidative stress markers and caregiver burden were assessed before and after.
Cureus · 2025 · PMID 40151718
Animal studies6
Male mice given MK-801 for four weeks were studied with hydrogen inhalation and comparison groups using behavioral tests and brain antioxidant assays. Animal n was not reported in the abstract.
Neuropsychopharmacol Rep · 2026 · PMID 41944455
In a mouse intracerebral hemorrhage model, oral hydrogen releasing nanosheets were compared with 3% hydrogen inhalation using behavioral, brain tissue and inflammatory assessments. Animal n was not reported in the abstract.
J Transl Med · 2026 · PMID 41654898
A mouse silicosis model received tetrandrine with hydrogen inhalation; histology, protein assays and single cell RNA sequencing were used. Animal n was not reported in the abstract.
Front Bioeng Biotechnol · 2025 · PMID 41561355
Eight female swine with induced mesenteric ischemia were compared in hydrogen inhalation and control groups of four; blood markers, intestinal histology and CT angiography were evaluated.
Acute Med Surg · 2025 · PMID 40626114
Mice with induced aortic dissection inhaled 2% hydrogen or control gas for 24 hours; aortic tissue, blood and bone marrow markers were measured. Animal n was not reported in the abstract.
Life Sci · 2026 · PMID 42105975
30 rats were allocated to control, myocardial infarction and myocardial infarction with hydrogen groups of 10. The hydrogen group inhaled 2% gas for three hours twice daily; cardiac tissue and mitochondrial markers were measured.
Free Radic Res · 2025 · PMID 40040521
Studies combining animal and cell experiments1
Hydrogen was studied in mice undergoing cerebral artery occlusion and reperfusion and in SH-SY5Y cells exposed to oxygen and glucose deprivation; tissue injury, cell viability, oxidative stress and proteins were measured. Animal and cell replicate n were not reported in the abstract.
J Stroke Cerebrovasc Dis · 2026 · PMID 42049119
Excluded 3 records. Gas exposure of artificial skin rather than inhalation: 1. Air pollution review rather than molecular hydrogen inhalation: 1. Nebulized hydrogen rich water rather than hydrogen gas: 1.
View the search query
(TITLE_ABS:"hydrogen inhalation" OR TITLE_ABS:"hydrogen gas inhalation" OR TITLE_ABS:"inhalation of hydrogen" OR TITLE_ABS:"hydrogen-oxygen inhalation") AND TITLE_ABS:"oxidative stress" AND (SRC:MED OR SRC:PMC) AND FIRST_PDATE:[2025-01-01 TO 2026-10-29]
Search Europe PMCFrequently asked questions
How many studies involved people?
One randomized trial, one comparative study without random allocation stated in its abstract, and one uncontrolled case report.
Are all sample sizes available?
No. Missing animal counts and cell replicate counts are explicitly marked as not reported in the abstract.
Does this list include hydrogen water studies?
The list covers hydrogen gas inhalation. A study using nebulized hydrogen rich water alone and an artificial skin gas exposure study were excluded.