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Evidence by topic

How has photobiomodulation been studied in Parkinson’s disease?

5 papers. Human observational studies without a separate control group: 2. Reviews and meta analyses: 2. Cell studies: 1.

First published from January 1 to October 29, 2026. All title and abstract search results in this period were screened.

Checked 2026-10-29 · 9 records searched

Human observational studies without a separate control group2

  1. Seven people with Parkinson’s disease used daily red or near infrared PBM on the head or inside the nose. Patients, spouses and clinicians observed nonmotor symptoms over 6 to 34 months in a case series.

    Int Rev Neurobiol · 2026 · PMID 42613143

    DOI 10.1016/bs.irn.2026.01.017Record and abstract

  2. Six people with Parkinson’s disease used transcranial LEDs and abdominal and neck lasers for five years. Stool 16S rDNA sequencing tracked gut microbial composition without a separate control group.

    J Clin Med · 2026 · PMID 41517622

    DOI 10.3390/jcm15010368Record and abstractFree full text

Reviews and meta analyses2

  1. Eight randomized and nonrandomized trials involving 279 adults with Parkinson’s disease were reviewed. Searches ran through May 2026; motor scales and walking tests were examined in meta analyses.

    Brain Sci · 2026 · PMID 42793350

    DOI 10.3390/brainsci16090925Record and abstractFree full text

  2. A narrative review examined PBM literature in Parkinson’s disease models and humans, covering mitochondrial, inflammatory, motor and nonmotor measures. The abstract does not report the number of papers or total sample size.

    Exp Neurol · 2026 · PMID 42926088

    DOI 10.1016/j.expneurol.2026.116088Record and abstract

Cell studies1

  1. Neuronal cells under Parkinson like oxidative conditions received near infrared PBM with liposomal rosmarinic acid. Mitochondrial and cell viability measures were examined; cell counts and replicate numbers are not reported in the abstract.

    ACS Biomater Sci Eng · 2026 · PMID 41587416

    DOI 10.1021/acsbiomaterials.5c01969Record and abstractFree full text

Excluded 4 of 9 records: broad mechanism or multidisease reviews (3), review centered on ultraviolet irradiation (1).

View the search query

(TITLE_ABS:photobiomodulation OR TITLE_ABS:"low level light" OR TITLE_ABS:"low level laser") AND TITLE_ABS:Parkinson* AND (SRC:MED OR SRC:PMC) AND FIRST_PDATE:[2026-01-01 TO 2026-10-29]

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Frequently asked questions

How many papers directly observed people?

This list includes two human studies without separate controls, observing seven and six people.

Were the 279 people newly recruited for the review?

No. They are the total participants in eight existing trials included in that review.

What methods were used in the cell study?

Neuronal cells received near infrared PBM combined with liposomal rosmarinic acid.