How has drinking hydrogen rich water been studied in metabolism?

36 adults with obesity were randomized under double blinding to one liter daily of hydrogen rich water or control water for eight weeks; appetite, body composition, sleep, circulating GLP-1 and lipids were measured.

Medicina (Kaunas) · 2025 · PMID 40731927

181 adults with metabolic or premetabolic syndrome entered a double blind randomized comparison of electrolyzed hydrogen water and filtered water for three months; waist circumference, glucose, oxidative markers and physical activity subgroups were assessed.

Antioxidants (Basel) · 2024 · PMID 38397743

73 people with impaired fasting glucose were randomized to one liter daily of hydrogen rich water or plain water for eight weeks. Metabolism and gut microbiota were measured; fatty liver subgroups comprised 16 hydrogen water and 19 control participants.

Antioxidants (Basel) · 2023 · PMID 37371975

30 people with fatty liver were randomized under double blinding to hydrogen rich water or placebo for eight weeks; weight, liver enzymes, lipids and blood biomarkers were measured.

Antioxidants (Basel) · 2022 · PMID 36290657

40 adults aged at least 70 were randomized to 0.5 liters daily of hydrogen rich water or control water for six months; protein and lipid metabolism, body composition, brain metabolism and other aging markers were assessed.

Exp Gerontol · 2021 · PMID 34601077

50 people with type 2 diabetes were randomized to electrolyzed hydrogen water or filtered water in a multicenter double blind study; insulin resistance, glucose, lactate and oxidative markers were assessed. Duration is not stated in the abstract.

Diabetol Int · 2021 · PMID 35059257

60 adults with metabolic syndrome were randomized under double blinding to high concentration hydrogen rich water or placebo for 24 weeks; body composition, glucose, lipids and inflammatory markers were measured.

Diabetes Metab Syndr Obes · 2020 · PMID 32273740

12 overweight people with fatty liver entered a double blind crossover trial of one liter daily of hydrogen rich water or placebo for 28 days; MRI liver fat, body composition and laboratory measurements were compared.

Clin Res Hepatol Gastroenterol · 2019 · PMID 30982748

30 people with type 2 diabetes and six with impaired glucose tolerance entered a double blind crossover study of 900 mL daily of hydrogen rich water or placebo for eight weeks per period, separated by a 12 week washout; glucose, insulin resistance and lipids were measured.

Nutr Res · 2008 · PMID 19083400

Nine adults with diabetes related blood markers outside reference ranges drank 1.5 liters daily of hydrogen water prepared by alternating current electrolysis for eight weeks; glucose, fructosamine and urinary oxidative markers were measured without a control group.

Med Gas Res · 2020 · PMID 33004708

20 patients with potential metabolic syndrome drank 0.9 to one liter daily of hydrogen rich water for ten weeks; lipoprotein composition and function and blood oxidative markers were measured before and after. A control group is not described in the abstract.

J Lipid Res · 2013 · PMID 23610159

20 adults with potential metabolic syndrome drank 1.5 to 2 liters daily of hydrogen water prepared using a magnesium stick for eight weeks; glucose, lipids and oxidative markers were compared before and after in an open label study.

J Clin Biochem Nutr · 2010 · PMID 20216947

A systematic review and meta analysis of hydrogen rich water and blood lipids in overweight or obese adults, searched through November 2025, covering 12 articles, 13 randomized trials and 757 participants.

Diabetol Metab Syndr · 2026 · PMID 41888952

A review of oral hydrogen rich water research, describing glucose and lipid metabolism measurements and other research methods. The abstract does not state an included study count.

Curr Pharm Des · 2025 · PMID 39810534

A systematic review and meta analysis of eight randomized trials with 357 participants examining hydrogen rich water and lipids in metabolic disorders, searched through January 2024.

Int J Endocrinol Metab · 2024 · PMID 39839806

A systematic review and meta analysis of seven studies on hydrogen rich water and lipid or lipoprotein profiles in clinical populations, searched through 4 October 2022.

Pharmaceuticals (Basel) · 2023 · PMID 37259294

Rats with streptozotocin induced diabetes received hydrogen rich water for 24 weeks; glucose, body weight, multiple organ histology and gene expression were analyzed. Animal count is not stated in the abstract.

Transl Androl Urol · 2025 · PMID 40687659

Mice with high dose steroid induced osteonecrosis received hydrogen rich water; circulating lipids, bone tissue, vessels and macrophage metabolic pathways were examined. Animal count is not stated in the abstract.

Biomaterials · 2025 · PMID 40411985

30 male rats were assigned to normal diet, high fat diet, or high fat diet plus oral hydrogen rich water for 16 weeks; weight, reproductive hormones and testicular tissue were assessed.

Toxicol Appl Pharmacol · 2025 · PMID 40188972

ApoE deficient mice with dyslipidemia and induced psoriasis like skin inflammation received hydrogen rich water; circulating lipids, skin inflammation and gene expression were analyzed. Animal count is not stated in the abstract.

Eur J Pharmacol · 2025 · PMID 39923825

12 mice with type 2 diabetes were assigned to hydrogen rich water or control water, six per group, from six weeks of age; weight, glucose, blood pressure and retinal blood flow were measured through 14 weeks of age.

Transl Vis Sci Technol · 2024 · PMID 39446362

HepG2 cells exposed to free fatty acids received hydrogen rich water; lipid droplets, oxidative stress and AMPK signaling were measured. Replicate count is not stated in the abstract.

Biomedicines · 2024 · PMID 39062020

Of 23 pregnant goats, ten received hydrogen rich water for 21 days before and after delivery and 13 served as controls; glucose and lipids were measured weekly and offspring growth was recorded.

Res Vet Sci · 2024 · PMID 38458045